Cardiology appointment 9-19-11

We had our monthly follow-up with Andrew’s cardiologist yesterday.  As much as I really like Andrew’s cardiologist, these appointments exhaust me.  Yesterday’s was no exception.  We knew going in that it would be a long afternoon with an echo, ekg and doctor appointment all in one.  In addition, the only appointment open in this time frame was in the main Phoenix office, which is much busier than the small Scottsdale office we usually frequent.

Andrew was great.  We talked before the appointment about what was going to happen at the doctor’s office.  He is obsessed with knowing “what next”.  After talking through the appointment many times, he was ready.  He smiled and charmed everyone.  We even saw our friend Steve who is the medical assistant in the Scottsdale office.  He wasn’t our medical assistant yesterday, but he stopped by to check out Andrew and give him knuckles.  Andrew weighs exactly 12kg or 26 1/2 pounds and is 38 inches tall.  Still a peanut!  His blood pressures were all his normal… low in the right arm (narrowing artery), really low in the right leg (occluded arteries in his groin) and good pressures in his left arm and leg (no issues there!).

He was such a good boy with everything… and is growing up so fast!  Yesterday, he laid on the table all by himself for his blood pressures and EKG.  Usually he sits in my lap, but he was was good on his own until the EKG stickers had to come.  Those are really sticky and he is still really protective of his “owies” on his chest.  The EKG looked normal… still no sign of the arrhythmias that he had post-op in the hospital.  However, we are also still on meds to prevent them from occuring.

Doing is all by himself... such a big boy!

Next up was an echo.  Andrew also did great with laying still and letting the tech “take his pictures”.  An addded bonus was that the movie Cars was playing on the tv in the echo room.  However, the tech finished too quickly… before Mater came on!  It was pretty cool because she took some time to make sure that I got to see his Fontan conduit and also his Glenn.  The bigger he gets, the easier it is for the tech to point out different things on the screen.  One our echo was done, it was back to the room to wait… and play cars!

The exam table makes a great race track or in this case, place to crash cars.

Then Dr. Lindblade came into check Andrew out and chat.  He is very impressed with how healthy and happy Andrew looks.  His lungs sound clear (yay! no chylothorax!) and his heart function looks great on the echo.  He still has mild regurgitation (leak) in his tricuspid valve.  This has always been mild to moderate, so no reason to be concerned about it now.  The fenestration (think pressure release valve) between his new fontan conduit and his heart is still being used.  Normal is a pressure gradient of 5-8 and Andrew’s is at about 8.  Because everything looks good, we get to come off of Digoxin.  Always good when we can lose a med.  However, we are staying with everything else for the time being.  So, Andrew is currently on 2.5mg of Enalapril (2x a day), 60mg of Amiodarone (1x a day), 15mg of Lasix (1x a day), 10mg of Aldactone (2x a day), 6mg of Sildenafil (3x a day), 81mg of Aspirin (1x a day) and 0.5mg of Coumadin (1x a day, Monday-Friday only).

So here is the plan… continue to go in every week or two for an INR check (coumadin levels and a whole post by itself!).  In a month, his INR check will also include getting a Holter Monitor.  Once the doctor gets the results from this Holter he will call us to discuss.  If all looks well, we may try to wean the Amiodarone at that time.  We go back to see Dr. Lindblade one month after that (2 months from now).  At that appointment, we will do another Holter Monitor to see how he is doing off of the Amiodarone.  If all looks well, then we will continue off of the Amiodarone.  However, if there is any sign of rhythm issues, we go back on it.  I have a feeling that we will be very used to wearing a Holter Monitor in the future!  However, it is a pretty easy thing to wear and it doesn’t seem to bother Andrew.

So overall, he is doing great!  He is enjoying school and looking forward to it getting cooler (hopefully soon!).  Thanks for checking in with us.  I will do another post just on the Coumadin and the battle of the INR after Friday’s check.

Fontan Rockstar

Andrew has definitely been a rockstar through this whole Fontan process.  He has very rarely complained, asks us before he eats anything (“Is this too much fat for me?”), doesn’t fuss too much about a finger poke for an INR test and takes a ton of meds like a champ (none of them are flavored).  We are so proud of him!

He continued his wonderful Fontan recovery today with a visit to our favorite cardiologist.  Andrew is such a big boy at these appointments.  He stands on the scale (still weighs 12kg/26lbs, same as 2 weeks ago), sits still for his blood pressure, EKG and sats.  The only fussing came with removing the EKG stickers (his chest is still pretty sensitive) and when they poked his finger for an INR check (coumadin level).  He is a solid 90% on his sats, EKG looked fine and the INR was 3.3 (range is 2-3).

His blood pressures were overall good.  Andrew has some funky issues that cause some pretty funny readings.  They like to check blood pressures in each of his extremities (both arms and both legs).  Andrew’s legs differed by about 30 on his systolic numbers (top numbers) from each other.  The left leg has a normal blood pressure while the right leg has a low blood pressure due to a cut down that was performed on his right groin when he was a baby.  Obviously there is a different blood flow to that leg.  Nothing to worry about, just something to remember.  His arms are similar… the left arm is about 10-15 higher than his right.  We are pretty sure that this is due to a narrowing in the innominant artery (from when he had a BT shunt) that goes from his aorta to his right arm, therefore lowering his blood pressure in that arm.  Again, nothing to be super worried about, just keep an eye on.

The best news is that his chest x-ray is clear!  No pleural effusions and no chyllothorax.  This means that Andrew can come off of the low fat diet.  He is so excited to eat fried mozzarella sticks (from Sonic), chicken nuggets (from McDonalds) and real bacon.  He was putting in his requests on the ride home.  He also can go back to school.  So tomorrow we will call and make the arrangements for him to go back on Monday.  He will only have missed the first four days.

We did come home with a new piece of equipment… a Holter Monitor.  This is like a portable EKG.  It records Andrew’s heart beat and rhythms for 24 hours.  There are 5 little stickers…

 

He also got this really cool shirt to keep the stickers in place…

 

 

 

 

 

 

 

 

 

Recovery Continues…

Sorry for the lack of posts… things have been going extremely well and we are slowly getting back to our normal lives.  John has been busy with marching band and music jobs, the kids are getting ready to start school and I have gone back to work.  Andrew is doing extremely well at home and that has been confirmed by a couple of doctor visits.

First, we saw Dr. Pearl, Andrew’s surgeon and Kristen, CV Surgery NP, last Friday.  Andrew had a chest x-ray as well.  They took a look and listen to Andrew and studied the x-ray and determined that he is healing very well.  Kristen removed the steristrips on Andrew’s chest and told him that he could now go swimming.  He was so excited to be able to get back into the pool.  We don’t have to go back and see them unless there is an issue.  Yay!!!

Today was our first post-op cardiology visit with Dr. Lindblade.  He also is very impressed with how well our little rock star is doing.  His incision continues to heal well and his lungs sound clear.  He weighed in at just over 26lbs (12kg) and his sats were in the low 90′s (Yay!!!).  Everything else was pretty normal.  No real concerns, but also not ready to wean meds yet.  So we remain on Enalapril (2.5mg per day), Amiodarone (60mg per day), Lasix (30mg per day), Aldactone (20mg per day), Sildenafil (18mg per day), Digoxin (50mcg per day), Aspirin (81mg per day) and Coumadin (0.5mg).  Andrew’s INR was 4.3 today (should be between 2 and 3), so we will skip tonight’s and tomorrow’s doses and restart on Saturday.

Cardiology is going to keep us on a pretty short leash for awhile.  Andrew will go back for another INR check on Tuesday and we are hoping to find a happy medium.  This is still a scary drug for us… if he hits his head, it is a trip to the ER for a CT scan.  For Andrew, a bonk on the head is pretty common… we are starting a pool for how many ER co-pays (only head or bleeding issues count) we can rack up by the end of the year!  If you want to take a guess, let me know.

We go back to see Dr. Lindblade in 2 weeks and will have another chest x-ray to check for effusions (fluid leaking into his chest).  If all is going well at this time and the x-ray is clear, then we may be able to begin to wean some meds.  At that time Andrew may also be released back to school.  If so, then he will only miss the first week of school.  At that appointment we will also do a Holter Monitor to check on his heart rhythm and make sure that we are still not having issues.

Overall, Andrew is doing great!  He has lots of energy and lots of appetite!  Thanks for checking in on us!

Home Sweet Home

So sorry for the lack of a post letting everyone know that we are now home!  Andrew was discharged about 3:00pm on Friday.  We arrived home at about 4:00pm, which was just enough time to run to the pharmacy and pick up the rest of his meds.  Because most of his meds are compounded, they have to be sent to a special pharmacy and they are only open until 5:30pm and are closed on the weekends.  Needless to say, by the time we were home and situated, we were all exhausted.  The weekend was wonderfully lazy.  It was great to spend time together as a family and all sleep under the same roof.  We had some family and friends come by, but mostly we laid around and watched tv.

Home after surgery means developing a new routine.  We have gone from one prescription med (Enalapril) twice a day with a low dose aspirin once a day to 9 medications, some of which are taken 3 times per day.  It is quite the schedule and is taking Andrew some time to get used to.  We have not had issues with taking medications before, but he is a little reluctant at the moment.  They all get down but not without some bribing along the way!  Andrew is home on Enalapril (to help with blood pressure), Digoxin (to help with heart function due to rhythm issues), Amiodarone (to help slow his heart rate to help with his rhythm issues), Lasix (to help keep off fluid), Aldactone (also to help with fluid), Sildenafil (to help keep the pathways to his lungs wide open), low dose aspirin (blood thinner), Coumadin (blood thinner) and Ibuprofen (for pain).  Most don’t taste very good but are little doses (2.5ML or less).  The one exception is the Amiodarone… it is almost 1/2 an ounce (12ML) and is a little hard to swallow.  Luckily, it is only once a day.

We may have figured out the Coumadin for the time being.  Andrew has to go in for INR checks to make sure that his dose is in the therapuetic range.  One of the fears that everyone has is that he will spike high again.  So far, so good!  His level this morning was absolutely perfect at 2.0.  We will go back in the clinic for another check (finger poke) on Thursday.  The goal is to have his level stable enough that we will only have to check once a month.  He needs the Coumadin, but it is a little scary… if he falls and hits his head, it is an automatic trip to the ER for a CAT scan.  Andrew falls a lot… hits his head a lot… should be fun for the next few months!

We also came home on a low fat diet to try to avoid chylothorax issues.  So far so good… he seems to like fat free hotdogs and cheese!  The trick is to get him enough calories that are not fat based and not have him lose any weight.  Not easy for a kid who was on a high fat diet!  We are hopeful that his voracious appetite and newly plumbed heart will help us out.  He has been a non stop eater for the past week!

Overall, it is wonderful to be home!  Andrew is napping and the girls are swimming (he can’t go in yet, so they have to do it during naptime!).  John is preparing for Band Camp at Mountain View this week and I have one more week before going back to work.  Andrew has follow-up appointments in the coming days… another INR check on Thursday, a chest x-ray and surgery follow-up on Friday and a cardiology appointment next Thursday.  Life seems to pick right back up where we left off before surgery… just with a few modifications.  We will keep everyone updated as we continue life post-Fontan!

The end is in sight…

Not much has happened over the past few days. Andrew has slowly and steadily improved. There is even talk of going home soon!

The chest tube drainage has slowed to almost nothing, but what does drain is very milky so he is leaking fats from his lymphatic system. They are going to pull the chest tubes today and see what happens. The nice thing is that the oxygen also gets to go with the chest tubes. Our little boy will be free from all of his tubes!

The coumadin has been restarted and so far, without disastrous results. Everyone is still confused by what happened last week with the crazy high INR readings. They gave him 0.5mg last night (same as the dose last week) and his INR this morning was only 1.4 which is not high enough (2 is the goal). Therefore, we will get a dose tonight and recheck the INR tomorrow morning.

If his chest x-ray is good in the morning and his INR is not way high, there is a good chance of being home by tomorrow evening. We are not banking on it because the minute you plan it, something will happen. In fact, we never say the word “home” in the ICU because it jinxes everything. Therefore, we continue to take it day by day and see what tomorrow holds.

The plan for today is to pull the tubes and then get out of our room and the unit. The intensivist (ICU doctor) is encouraging us to take him outside. There is a beautiful rooftop garden on the 3rd floor, so we will go explore that later today. They also encouraged us to take him to eat in the cafeteria, even if only for a snack. We have explored the new hospital, but Andrew has not had that opportunity. He does enjoy walking the unit and peeking in each room. We thought he was looking for new girlfriends but his intentions are more self-serving. He wants to check out what everyone is watching on tv to see if its better than what is on in his room. He has become quite the couch potato!

Again, thank you for all of the support. We are all doing well and excited to be a family under one roof. We will post as things happen, so watch here and the twitter feed on the side!

It Has Been One Week

It was one week ago today that Andrew had surgery. He has come so far in one week. He is walking around the unit, riding in a wagon, eating and starting to play. Andrew’s personality is beginning to show through again and he is talking up a storm. Much better than the first several days when he would just cry or ignore everyone.
However, he is “all done with hospital”. Andrew is so tired of being messed with that he cries when anyone wants to do anything more than a basic assessment. At least he tolerates being assessed, but if they have a syringe or anything else in hand, he starts to cry. It definitely is difficult at this age for him to understand what is going on, but he is doing his best to cooperate.
One of the big things is medicine. Andrew has been on medicine since he was born. It is a fact of life for him… he takes medicine in the morning and before bed. However, he was on one prescription med (Enalapril) twice a day and one baby aspirin per day. We are now on 6 liquid meds (Enalapril, Digoxin, Amiodarone, Sildenafil, Lasix and Aldactone). At 9am we take all of them. At 3pm he takes Sildenafil and Lasix since they are taken 3 times per day and at 9pm we take all of them but Digoxin (only once per day). In addition, he takes a baby aspirin and another blood thinner (see below for that story). He also is on Ibuprofen every 6 hours and Loritab as needed. Our little boy who never fussed about taking meds now cries when he sees the syringes. Hopefully as we wean off of some of these over the next few months, it will get better.
Our current plan is to continue to heal and hopefully stop draining fluid through the chest tubes. We have been watching his drainage carefully for signs of Chylothorax. When this happens, they put patients on an extremely low fat diet. This weekend we have been borderline. He is leaking fats, but his drainage is tapering off, so the doctors are just watching and waiting. They suggested that we voluntarily modify his diet to not be so high fat. The difficulty with a low fat diet is that Andrew depends on fats for calories and has always been on a high fat diet. He has never really been exposed to low fat foods because every bite he took had to contain as many calories as possible. His surgeon remarked last night that they may have created a monster! The nutritionist is supposed to come and help us today with a new high calorie diet without lots of fat.
The other big issue is the addition of a blood thinner. The surgeon likes Fontan kids to be on Coumadin for 3-6 months. Because Coumadin is such a sensitive drug, they draw blood to check an INR level. The therapeutic range for Andrew is between 2 and 3. Andrew received 1 dose of Coumadin (0.5 mg) late Wednesday afternoon. Thursday his INR was 2.9, so they did not give him his Thursday dose. On Friday, his INR was over 8 on the first test and just under 8 on the second. Needless to say, Andrew did not get another dose. No one is sure why Andrew reacts to Coumadin like that. One thought is that the Amiodarone that he is taking for his rhythm issues makes the Coumadin more effective. It was Sunday before his level came down enough that they need to give him more.
Before they give Coumadin again, they want to pull his last central line. His RA line goes directly into his heart. They do not want to pull this line while his INR is high, so the plan was to pull it and then give Andrew the Coumadin. They were getting ready to pull it yesterday when it was discovered that this was the only IV line that Andrew has. All his others have been pulled which would leave them no way to give him IV meds if needed or to draw blood without sticking him. So today, they will put in a picc line which will allow them IV access and also to draw blood. Once this is in, then they will pull the RA line. At least this was the plan yesterday. Rounds have not yet started today so we will have a better idea of what will happen after rounds.
Sorry for the long post… wireless access has been spotty at best on the 5th floor (still working out bugs in the new hospital!). I can post to Facebook and Twitter from my phone, but blog posts are more difficult. It seems that they are fixing the problem, so hopefully I will be able to post more often and with pics! Thanks for all of the support!

Post-op Day 4: A Few Bumps

Yesterday (day 3) was the best day Andrew has had all week. By the evening he had started to use his hands to eat Goldfish crackers and play with some cars. He was starting to smile more and just seemed happier.

Last night he had an overall good night. Daddy stayed with him while I went home to sleep. For the past several nights, we have both been staying with him. It felt great to go home and get a full nights sleep. John is going to be home tonight while I stay with Andrew.

This morning saw a few new developments… Some good but some a little interesting and confusing. The goood news is that his chest tube drainage was still trending down. The first 24 hours he was over 800 and the 2nd saw 700. The last 24 hours saw it decrease to about 500. Still a lot, but on the right track. However, today is going to break that trend. In the first 6 hours he put out about 200. This is what keeps kids in the hospital… Waiting around to stop draining. The good news is that it is still clear, so no low fat diet yet (they still expect Andrew to leak lymphatic fluid which is cloudy).

The interesting development is with Andrew’s blood work. His clotting factors were all out of whack this morning. The most concerning being his INR which helps dose his coumadin. He took his first dose Wednesday evening. His level yesterday morning was a little high, so they didn’t give him any yesterday. This morning his results stumped everyone. His INR was significantly increased and at a dangerous level. They are trying to figure out if there is some kind of drug interaction taking place. His levels should not have increased without a coumadin dose yesterday. Waiting to see what they figure out.

They were going to remove the IJ line in his neck today, but with such high INR levels, it is too risky and he could bleed way too much. So the line stays in until his levels come down. So the plan today is to get him out of bed and out of the room today. He sat in a chair for a couple of hours and this afternoon we are going to ride in the wagon and try to walk a little bit. He is really fussy today and his blood pressure is higher, so we are thinking that he may be hurting little bit. He is currently resting up (sleeping off the Morphine) before we head out on our wagon.

I think that we have figured out how to work around so e techie issues, so hopefully I will be able to post more.

Post Fontan Day 2

Sorry for the lack of blog posts. We have had a horrible time connecting to wi-fi the past couple of days. Even doing updates from the IPhone weren’t posting. Very weird. Luckily, we have gotten our Apple products to connect but the PC laptops are another story.

Andrew continues to slowly get better. Yesterday was a very rough day, but today is better. While we aren’t getting very many smiles, we are starting to see our Andrew come back. Overall, he is still fairly grumpy, moody and whiny!

While they are working on getting him to eat and drink more and also get out of bed, there are two bigger issues. As with a lot of Fontan kids, Andrew’s chest tubes are draining like crazy. The rate has increased significantly over the past 24 hours. There is a strong suspicion that we may be here for several days until it clears. We were prepared for this since it is one of the more common issues after surgery. We also know that Andrew likes to do the opposite of what everyone thinks, so we really hope that he is listening!

There is one issue that has popped up that we were not expecting is the funny heart rhythm that is going on (another Andrew trait!). It is an atrial bigeminy rhythm. My basic understanding is that there is a regular heart beat quickly followed by a “false beat” that comes from only the top chamber of the heart (atria). Then there is a gap followed by another heart beat. We can see it quite clearly on all of his monitors and was quite the dominant issue during an echo today. Basically, it looks like Andrews heart rate is 160 (which is fast for him). However, only about 80 beats (slow for Andrew who is usually 100-110 bpm) are “profusing” or capable of sending blood to the tissues.

It is not a super dangerous rhythm as long as Andrew tolerates it well. However, it was decided early on by cardiology to treat it right away. Everyone remembers Andrew and his penchant for throwing big curveballs. Basically, the cardiologist in the ICU “doesn’t trust” Andrew. Therefore, he is on an IV drip of amiodrone to slow his heart rate way down. The they set the pacemaker at a faster rate than his heart so that the pacemaker dictates the heart rate. In order to “capture” the atrial beats, the pacemakeris set at 145 beats per minute (bpm). The pacemakers external. They always place pacer wires during surgery just in case of things like this. They are just pulled when not needed anymore.

We are in major wait and see mode. It is too early to speculate how long we will be here. It is too early know if drainage will be a huge issue or if the the rhythm issue is temporary or permanent. Cardiology thinks we will go home on the amiodrone because the rhythm issue won’t clear before we go home. Surgery thinks that Andrewis going to drain fluid from. His chest tubes for awhile so we have plenty of time to settle out the rhythm issue. It’s up to Andrew and his system to figure it all out!

The best news is that Andrew is more alert and active. He is doing so well with all of the procedures and meds. While he will voice his displeasure and sometime fight, overall he is cooperative and sweet. We can’t say enough about the wonderful doctors, nurses, child life specialists and staff who take such good care of our baby. The new CVICU is very nice, even with some hiccups. We also have such wonderful friends and family taking care of us.

Hopefully we will get our tech issues figured out so I can update more (hopefully with pics!). Thanks for all of the prayers!

Fontan Recovery- 1st night

Sorry for the lack of update on the blog. It has been a roller coaster of an afternoon and evening. Plus my laptop and the hospital wi-fi can’t seem to play nice. Luckily, I can use the IPad…

The surgery went very well. Dr. Pearl was able to put in an 18mm conduit which is adult size. No issues in the OR, just a few encounters with scar tissue.

The real fun began once Andrew arrived in the CVICU. For some reason, all of his numbers changed. He was having a difficulty with keeping his blood pressure up and his heart rate down. He also began to run a fever.

Then about 4:00, things went crazy for about 20 seconds… His heart rate jumped to over 250 and his blood pressure in his arterial line dropped to zero. His body snapped out of it, but it was enough to concern the cardiologist. They gave him a medicine to help slow his heart rate which was still over 165. It helped to bring down his heart rate and there was talk of taking him off of the ventilator.

That quickly changed when his heart began to beat irregularly. It seems that his atrium (upper chamber) wants to beat more often than the ventricle (lower chamber). This causes the monitor to show an extra heartbeat. However, his body seems to like this new rhythm. His blood pressure has remained stable. However, he is now on a full drip of the medicine to help his heart beat regularly.

He was taken off of the ventilator at about 10:00pm. He is on oxygen but getting better at keeping his sats above 80%. He is awake for short periods of time and is telling us what he wants (a drink, water, all done, go home now, hold me). Unfortunately, we have to tell him no on all of these, but he doesn’t get too upset and then goes back to sleep. He only freaks out whe he can’t see one of us (hence the lack of updates to the blog).

We have been very blessed with wonderful doctors and nurses. The nurse we had this afternoon remembers us from when Andrew was a baby. The doctors have been great at listening and responding. Tonight we are very lucky… our favorite nurse offered to work tonight if she could take care of Andrew. She is absolutely wonderful and adores Andrew. On top of that, Dr Lindblade, Andrew’s cardiologist is on call tonight and has been working with the intensivist. Everyone is keeping such a close eye on him. Having a reputation of being a trouble maker has it’s perks!

It is too late (1:30am) to try to spell the type irregular heart rhythm He has or the medicine he is on. I will post more details in the morning, probably after rounds. Since it is easier to post the little things to Twitter, watch for the updates there. I am hoping to figure our the laptop issue so I can post some pics.

Thank you for all of the well wishes, thoughts and prayers. Thank you to friends and family who have come by, brought dinner, watched our girls and all of the numerous little things that allow us to focus on our little hero!

Pre-op Fun

The Day of the Fontan started early… the alarm went off at 4:20am so that we could be at the hospital between 5:30 and 6:00am. Got off to an exciting start when we realized that we woke up to pouring rain… not something we see often in the desert!

Once we arrived at the hospital, things went somewhat smooth at first. Andrew is still flagged for his previous MRSA infection, so we had to stay and play in our own room. No problem… we snagged a car to ride around in and played on the Ipad.

All was going well until the nurse came in… she had to deliver the news that they needed to draw more blood. The blood that they drew on Friday tested positive for a certain type of protein. Because of that, they had to run more tests and there wasn’t enough blood to finish, so they needed more. Andrew was not thrilled in the least, but he was such a big boy! Only two nurses were needed this time around.

The protein that they found in his blood (has a long name that I will have to have them write down later) causes his blood to clot in extreme cold. Dr. Pearl was notified of this last night and explained to us that it takes more cold than what we get here. However, it means that he needs to be careful when they cool Andrew’s body for surgery. Instead of 30-32 degrees, they will probably only go down to 34. Dr. Pearl didn’t seemed to concerned, but leave it to Andrew to throw a curveball every once in awhile.

After that, things went well and quickly. They gave Andrew Versed to relax him for the trip to the OR. It worked great! Within about 10 minutes, he was giggling up a storm. We were highly entertained watching Andrew play Angry Birds and watch You Tube videos.

It is never easy to leave him as he goes to the OR, but we have looked forward to this last stage for so long, it does feel good to get it started. He went in about 8:00am and we are awaiting the first updates as it will take a couple of hours to get started (we just got word at 9:50am that they were finally starting surgery). Thank you for all who are praying for us today!